Supplements & Compounds Hub

A comprehensive, evidence-based reference library covering the most clinically relevant supplements and compounds — organized by category, grounded in mechanisms, and designed for integrative practice.

Categories

CAT 1: Vitamins

Essential micronutrients divided by solubility — fat-soluble vitamins are stored in body tissue and require dietary fat for absorption; water-soluble vitamins are not stored and must be replenished daily.

FAT-SOLUBLE VITAMINS (A, D, E, K)

Stored in body fat and liver. Require dietary fat for absorption. Accumulate over time — toxicity possible at high doses. Dosing and cofactors matter.

WATER-SOLUBLE VITAMINS (B-COMPLEX & C)

Not stored in the body — excreted daily via urine. Must be replenished consistently. Excess generally safe; deficiency develops faster than with fat-soluble vitamins.

CAT 2: Minerals & Trace Elements

Essential minerals divided by required quantity — macro-minerals are needed in hundreds of milligrams daily; trace minerals are required in microgram-to-low-milligram amounts but are equally critical to enzymatic and hormonal function.

MACRO-MINERALS

Required in amounts of 100mg+ daily. Structural and electrolyte roles — bone, muscle contraction, nerve signaling, fluid balance, and energy metabolism.

  • Calcium: The Bone-Building Mineral — Most abundant mineral in the body; 99% in bone as hydroxyapatite. Requires D3 and K2 for proper absorption and tissue direction. Calcium citrate preferred over carbonate in low-acid environments.
  • Magnesium Deficiency: Root Causes & Integrative Protocols — Cofactor for 600+ enzymatic reactions. Deficiency drives anxiety, insomnia, muscle cramps, insulin resistance, and cardiovascular risk. Glycinate and malate forms preferred for absorption and tolerability.
  • Phosphorus: Energy, Bones & Cell Health — Second most abundant mineral; essential for ATP synthesis, DNA/RNA backbone, and phospholipid cell membranes. Rarely deficient in Western diets; risk in refeeding syndrome and antacid overuse.
  • Potassium: Electrolyte Balance, Heart Health & Muscle Function — Primary intracellular cation. Critical for cardiac rhythm, blood pressure regulation, and neuromuscular function. Depleted by diuretics, excessive sweating, and low-carb diets.
  • Sodium & Electrolyte Balance — Primary extracellular cation governing fluid volume, nerve conduction, and osmotic pressure. Hyponatremia is as dangerous as hypernatremia — balance with potassium and magnesium.
  • MSM (Methylsulfonylmethane): Joints, Detox & Cellular Health — Organic sulfur compound; third most abundant mineral in the body. Essential for collagen synthesis, glutathione production, and Phase II liver detoxification (sulfation pathway).

TRACE MINERALS

Required in microgram-to-low-milligram amounts. Enzymatic cofactors, antioxidant defense, thyroid function, and immune regulation — small doses with outsized systemic effects.

Fat-Soluble Compounds in This Library

The following compounds throughout CAT 3–12 require dietary fat for optimal absorption and may accumulate in tissue — take with meals containing healthy fats: CoQ10, Curcumin, Astaxanthin, Resveratrol, Pterostilbene, Fisetin, Quercetin, Sulforaphane, Modified Citrus Pectin.

CAT 3: Amino Acids & Peptides

Essential and conditionally essential amino acids and therapeutic peptides — the building blocks of tissue repair, neurotransmitter synthesis, immune function, and cellular energy.

CAT 4: Adaptogens & Botanicals

Adaptogenic herbs and botanical compounds that modulate the HPA axis, reduce cortisol burden, enhance stress resilience, and support hormonal and immune balance.

CAT 5: Nootropics & Brain

Evidence-based cognitive enhancers and neuroprotective compounds targeting acetylcholine synthesis, neuroplasticity, nerve growth factor, and brain membrane integrity.

CAT 6: Metabolic & Blood Sugar

Compounds targeting insulin resistance, glucose metabolism, AMPK activation, and mitochondrial function — foundational to metabolic syndrome reversal and longevity.

CAT 7: Longevity, Senolytics & Antioxidants

Senolytic flavonoids, NAD+ pathway activators, and polyphenolic antioxidants targeting cellular aging, autophagy, telomere integrity, and oxidative stress.

CAT 8: Hormonal & Endocrine

Hormonal precursors and endocrine modulators targeting the adrenal, thyroid, and sex hormone axes — supporting estrogen metabolism, testosterone, and cortisol balance.

CAT 9: Gut & Digestive

Compounds targeting the gut microbiome, intestinal barrier integrity, digestive enzyme sufficiency, and the gut-brain axis — foundational to systemic health.

CAT 10: Cardiovascular & Lipids

Evidence-based compounds for lipid modulation, endothelial function, arterial health, platelet regulation, and cardiovascular risk reduction beyond conventional pharmacology.

CAT 11: Detox & Liver

Hepatoprotective compounds, Phase I/II detoxification cofactors, bile acid modulators, and GI binders for toxin clearance, liver regeneration, and systemic detoxification support.

CAT 12: Specialty & Immune

Targeted immune modulators, antiparasitic compounds, antifungal botanicals, and specialty compounds with unique mechanisms not covered in other categories.

Reference Tables

Master reference tables for micronutrients, evidence-based compounds, and therapeutic peptides — designed for practitioners and advanced learners.

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